Therefore, the circulating levels of interleukin-6, tumor necrosis factor-α (TNF-α), interferon-γ, monocyte chemo attractant protein-1 (MCP-1), and wide-range C-reactive protein (wrCRP) were found to be increased in ALS patients (Robelin and Gonzalez De Aguilar, 2014). Here, TNF is linked to amyotrophic lateral sclerosis.