Another 5 percent of familial cases and < 1% sporadic cases results from mutations in the gene FUS, which encodes fused in sarcoma/translocated in liposarcoma (FUS/TLS), and three percent of the remaining familial cases result from mutations in TARDBP gene, which encodes TAR DNA binding protein-43 (TDP-43; Robelin and Gonzalez De Aguilar, 2014). The gene discussed is TARDBP; the disease is sarcoma.