POU5F1 and gastric cancer: Furthermore, Hayashi and colleagues (33) have shown that in gastric cancer OCT4-pg1 is overexpressed due to a genomic amplification (the OCT4-pg1 gene is located on chromosome 8q24 and is coamplified with its neighbor c-MYC) and that the OCT4-pg1 protein exerts an oncogenic role by promoting proliferation and angiogenesis while inhibiting apoptosis.