Shi and Erf in Smyth line (SL) chicken model for autoimmune vitiligo have shown that IFN-γ, a proinflammatory cytokine which acts as a signature cytokine of Th1 mediated immunity, has remarkably increased in the Smyth line vitiligo samples proving the central role of this cytokine in the SLV pathomechanism [19]. This evidence concerns the gene IFNG and vitiligo.