In last decade, several cohort studies among healthy people evaluated various inflammation markers, mainly interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α), as predictive of risk of overall cancer and particularly colorectal, breast, lung, liver and prostate cancer, with inconsistent findings [2–4, 20–26]. The gene discussed is TNF; the disease is cancer.