Homologous recombinationBRCA1 (breast cancer susceptibility gene 1) – gene knockout by rAAV – model for breast cancer (Luo et al., 2011, 2012)∗Introduction of missense mutation via rAAV – TP53 gene – cancer cells (Sieren et al., 2014)Introduction of nonsense mutation via rAAV – SCN5A gene – cardiac arrhythmia (Park et al., 2015). This evidence concerns the gene TP53 and chronic obstructive pulmonary disease.