CTLA4 and cancer: Therapeutic anti-cancer vaccines are expected to be important in the future immunotherapeutic treatment of cancer, either alone or in combination with, e.g., administration of drugs targeting the checkpoint inhibitors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) (Hodi et al., 2010; Brahmer et al., 2012; Topalian et al., 2012; Hamid et al., 2013; Wolchok et al., 2013).