CD8A and cancer: Previous studies have confirmed the involvement of CD8+ T cells in anti-cancer immune reactivity (Klebanoff et al., 2005; Sørensen et al., 2011b; Andersen, 2012; Joyce and Fearon, 2015; Rosenberg and Restifo, 2015) and anti-cancer vaccines are generally administered with the aim of enhancing this antigen- specific T-cell reactivity.