Collectively, however, the current data based on quantitative analysis of BAP1 protein interactions and target genes identification implicate transcriptional de-regulation in the pathogenesis of BAP1-associated mesothelioma, renal cancer and myeloid neoplasia (Bott et al., 2011; Dey et al., 2012; Peña-Llopis et al., 2012). This evidence concerns the gene BAP1 and renal carcinoma.