BAP1 and cancer: Indeed, shRNA-mediated silencing/loss of Bap1 results in defective DSB repair (Nishi et al., 2014; Yu et al., 2014) and Bap1-null cancer cell-lines are hypersensitive to IR (Nishikawa et al., 2009; Bott et al., 2011; Peña-Llopis et al., 2012; Ismail et al., 2014; Yu et al., 2014).