As to the other DUBs discussed in this Review, cross-cancer genetic alterations of the H2A-DUBs USP3, USP16, USP44 and MYSM1, as well as for BRCC36, OTUB1, OTUB2 have been reported (cBio Portal for cancer genomics, http://www.cbioportal.org/index.do; Dong et al., 2003). The gene discussed is OTUB2; the disease is cancer.