In line with an involvement of the RNF8-RNF168 pathway in hematopoiesis, inactivating mutations in RNF168 are associated with the RIDDLE syndrome, characterized by cellular radiosensitivity and immunodeficiency (Stewart et al., 2009), features which are recapitulated in knockout mouse models for these E3s (Li et al., 2010; Santos et al., 2010; Bohgaki et al., 2011). Here, RNF168 is linked to immune system disorder.