APOE and early-onset autosomal dominant Alzheimer disease: For example, in the Alzheimer’s disease Neuroimaging Initiative (ADNI) data set, structural imaging and genetic data from late-onset Alzheimer’s disease (LOAD) and healthy control subjects identified SNP components whose pathway analysis included genes already known to contribute to LOAD risk (e.g., APOE4) or involved in LOAD-related pathologic processes, including inflammation, type-2 diabetes, obesity and cardiovascular disease, plus significant novel genes.