Regarding T1D, it has been shown that tDCs modulated with IL-10 and TGF-β and loaded with the pancreatic islet autoantigens insulin or glutamic acid decarboxylase 65 (GAD65) were able to induce antigen-specific hyporesponsiveness in CD4+ T cells from patients in vitro (7). This evidence concerns the gene INS and type 1 diabetes mellitus.