Concerning RA, Harry and coworkers showed that tDCs from healthy donors and RA patients generated in the presence of dexamethasone, vitamin D3, and MPLA, and loaded with tuberculin purified protein derivative (PPD), induced only poor antigen-specific proliferation and production of IFN-γ and IL-17 by autologous T cells, even when T cells were previously primed by PPD-loaded mature DCs (8). The gene discussed is IFNG; the disease is rheumatoid arthritis.