• Uptake of aging or apoptotic RBCs (2)• Limitation of autoimmunity (IL-10 and TGFβ in resolution of inflammation) (55)• Induction of Tregs by IL-10 production (55)• Phagocytosis of blood-borne pathogens (35–38)• Iron homeostasis (1, 50–53). Here, TGFB1 is linked to Autoimmunity.