IFNG and neoplasm: Before the discovery of Th17 cells and their signature cytokine IL-17, it was assumed that early IFN-γ derived from γδ T cells was the main pathogenic cytokine driving EAE; this was in part based on the established role of IFN-γ-secreting γδ T cells in enhancing CD4+ and CD8+ T cell responses in anti-tumor immunity (36).