The most peripherally localized bacteria which contact neutrophils express anti-phagocytic virulence factors, e.g., YopE, the bacteria growing on the exterior of the microcolony induce the nitric oxide (NO)-detoxifying gene hmp and prevents NO diffusion and elimination of the interior bacterial population and illustrates a sophisticated form of division of labor during infection (Davis et al., 2015). This evidence concerns the gene IMMT and infection.