LHCGR and Leydig cell hypoplasia, type 1: In this context, the naturally occurring deletion in LHCGR of the complete exon10-encoded segment (LHCGR-delExon10), corresponding to 27 amino acids (Figure 2A) within the hinge region of the hLHCGR, could be directly linked to a case of type 2 Leydig cell hypoplasia in which the natural hLH-, but not hCG-induced function was disturbed (8, 9).