IFNA1 and Autoimmunity: Taken together, these data support two potential mechanisms by which genetic susceptibility can contribute to IFN-induced T1D: (1) some individuals inherit classical T1D susceptibility genes and IFNα simply triggers or accelerates the progression of T1D in them; alternatively, (2) other individuals inherit genetic variants that uniquely predispose to IFNα-induced autoimmunity.