Interestingly, spontaneous ARIA and CAA-ri have been also described in familial forms of AD (FAD), i.e., in AβPP duplication carriers (33), in presenilin 1-associated FAD (I202F PSEN1 mutation) (34), and in two siblings carrying the P284S PSEN1 mutation (35). This evidence concerns the gene PSEN1 and Alzheimer disease.