FREM3 and major depressive disorder: A SNP (rs7676614) within the human FRAS1-related extracellular matrix protein 3, encoded by the FREM3 gene, was among the top hits in an early GWAS of MDD, where the major A allele was associated with nominally higher risk relative to the minor G allele (p = 9.52 × 10−5 meta-analyzed across two independent samples) (Muglia et al., 2010).