Indeed, drawing on prior work suggesting a general convergence of depression-associated molecular pathway dysregulation across diverse brain regions such as the ACC (Tripp et al., 2011), dorsolateral prefrontal cortex (dlPFC) (Sibille et al., 2011), and the amygdala (Sibille et al., 2009; Guilloux et al., 2012), we believe FREM3 genetic variation would similarly impact expression patterns throughout the majority of cortical structures implicated in depression. Here, FREM3 is linked to major depressive disorder.