Systemic deficit in CD4(+) TCRβ(+) Foxp3(+) CD25(+) T regulatory cells, increased IL 6 and IL-17 production by CD4(+) T cells, and elevated levels of peripheral Gr-1(+) cells; hematopoietic stem cells exhibit altered myeloid lineage potential and differentiation; behaviorally abnormal MA offspring that have been irradiated and transplanted with immunologically normal bone marrow from either MIA or control offspring no longer exhibit deficits in stereotyped/repetitive and anxiety-like behaviors. The gene discussed is CD4; the disease is Anxiety.