Indeed, the binding regions of EP300, CEBPB, and HDAC2 in the promoters of transferrin (TF; Supplementary Figure S2), insulin-like growth factor binding protein 1 (IGFBP1; Supplementary Figure S3) and NQO1 (Supplementary Figure S4), whose expression was increased in obesity and was normalized by CR or RSV (Figure 6A), overlap. The gene discussed is IGFBPL1; the disease is obesity due to melanocortin 4 receptor deficiency.