Indeed, the binding regions of EP300, CEBPB, and HDAC2 in the promoters of transferrin (TF; Supplementary Figure S2), insulin-like growth factor binding protein 1 (IGFBP1; Supplementary Figure S3) and NQO1 (Supplementary Figure S4), whose expression was increased in obesity and was normalized by CR or RSV (Figure 6A), overlap. Here, EP300 is linked to obesity due to melanocortin 4 receptor deficiency.