A role for the 5-HT1A receptor was also observed in the light/dark test, where antagonists show an anxiolytic-like effect (Maximino et al., 2013c), and in the novel tank test, where antagonists can either increase (Nowicki et al., 2014) or decrease (Maximino et al., 2013c) anxiety-like behavior. This evidence concerns the gene HTR1A and Anxiety.