SLC17A7 and Parkinson disease: In line with evidence that the activity of the hyperdirect corticosubthalamic projection is altered in PD (Mathai and Smith, 2011; Yamawaki et al., 2012; Shimamoto et al., 2013; de Hemptinne et al., 2013; Delaville et al., 2015), we found a significant breakdown of the corticosubthalamic projection, characterized by a profound loss of vGluT1-positive terminals in the STN of parkinsonian monkeys (Mathai et al., 2015; Figures 3, 4).