The GluN2A subunit has been previously shown to increase due to epileptic activity in animal seizure models (Hellier et al., 2009; Gibbs et al., 2011; Reid et al., 2012; see Chen et al., 2007 for a reduction of GluN2A following flurothyl-induced recurrent neonatal seizures), which may also be associated with mossy fiber sprouting (Swann et al., 2007b). This evidence concerns the gene GRIN2A and Neonatal seizure.