Thus it is assumed that distinct alterations of the NRG1-ErbB pathway do not only lead to HSCR, that display complete aganglionosis, but may also be associated with or contributed to other enteric neuropathies probably characterized by a partial loss of enteric neurons (hypoganglionosis), e.g., slow-transit constipation or diverticular disease (De Giorgio and Camilleri, 2004; Wedel et al., 2010), all disorders belonging to the group of gastrointestinal neuromuscular diseases (GINMD; Knowles et al., 2010). This evidence concerns the gene NRG1 and diverticular disease.