CXCL8 and ischemic stroke: Similarly, the chemokines CXCL1, CXCL2, and CXCL8 were shown to have neuroprotective effects in a model of β-amyloid toxicity in vitro (Watson and Fan, 2005), however in vivo neutralization of CXCL8 has been shown to mitigate neurological and histological deficits in a model of ischemic stroke (Villa et al., 2007).