In an in vitro study on frozen postmortem brain tissues from cases with different neuropathological states of AD and age-matched controls, an enhanced expression of CX3CL1 in brain regions with more vulnerability to AD-related changes, such as hippocampus, has also been noted where the level of CX3CL1 expression reflected the course of disease (Strobel et al., 2015). The gene discussed is CX3CL1; the disease is Alzheimer disease.