ARC and memory impairment: In terms of its role in memory formation, numerous studies have reported memory impairments following global or region-specific inhibition of NF-κB activity in a diverse group of organisms and transcription of several genes has been shown to be dependent on NF-κB activation, such as zif268/egr1 and Arc (O’Mahony et al., 2006; Zalcman et al., 2015), which have well described roles in the memory consolidation process (Guzowski et al., 2001; Hall et al., 2001; Ploski et al., 2008).