BACE1 and Alzheimer disease: APP and the β-secretase BACE1 are sorted by the Golgi into different compartments and the loss of the sorting function of the Golgi by fragmentation in AD results in defective trafficking of APP and BACE1, which promotes Aβ production (Tan and Evin, 2012; Das et al., 2013; Joshi et al., 2014).