Median platelet count was only significantly higher at week 4 of treatment among patients with normal ITPase activity compared to patients with ITPase deficiency (144x109/L, (IQR 103–196) vs 132x109/L, (IQR 99–160); p = 0.040, Fig 1B). This evidence concerns the gene ITPA and hyperinsulinemic hypoglycemia, familial, 4.