Mice in which the wild-type (WT) GR was replaced with a mutant with impaired dimerization, and therefore reduced gene transactivation ability (GRdim), were found to have higher mortality and elevated levels of TNF-α, IL-1β, and IL-6 compared to WT mice in two sepsis models, cecal ligation, and puncture and LPS [16]. This evidence concerns the gene TNF and Sepsis.