IFNG and Sepsis: Although no elevation in IL-12 and IFN-γ was observed in LPS-treated GRdim mice [16], recent evidence shows that GRdim is still able to repress proinflammatory gene transcription through a mechanism that is independent of the dimerization domain [reviewed by 34], leaving open the question of whether IL-12 production by DCs is regulated by endogenous GC during sepsis.