In the stratified analysis by cancer types, IL–10 overexpression was associated with worse 3-year OS of digestive system cancer (OR = 3.79, 95% CI = 2.61 to 5.50, P < 0.0001) and lymphoma (OR = 2.23, 95% CI = 1.24 to 4.01, P < 0.0001) (Fig 3). This evidence concerns the gene IL10 and digestive system cancer.