Although the relevance of ADARs and RNA editing in cancer just begins to be recognized (Avesson and Barry, 2014, Han et al., 2014, Mo et al., 2014, Salameh et al., 2015, Witkin et al., 2015), the link between A-to-I editing by ADAR and the type I interferon response shown in our study suggests that the cancer immune response can influence ADAR’s activity, as shown in other systems. The gene discussed is ADAR; the disease is cancer.