PRRT2 and mood disorder: In the specific case of the amygdala, a number of signal transduction pathways have been implicated in modulating the cellular systems that control mood.36 One of the best studied is the PKA signal transduction pathway that is activated in amygdala neurones by binding of stress released epinephrine to B1 adrenergic receptors.36 Because of the known contribution of chronic stress in the exacerbation of mood disorders we sought to determine the effects of agonists of signal transduction pathways such as PKA and PKC known to have a role in amygdala function.