BICC1 and major depressive disorder: Using genome wide association studies we previously demonstrated that a significant association existed between the rs9416742 and rs999845 polymorphisms (P=1.3 × 10−7 and 3.14 × 10−7, respectively) and susceptibility to MDD.7 As previously mentioned neither of these SNPs occur within any coding regions of the BICC1 gene nor were they in LD with coding SNPs.