TLR5 and rheumatoid arthritis: Due to lack of association among seropositive RA patients with the TLR5 polymorphism, we explored other clinical variables of importance for this association using linear regression analyses of the association between the TLR5 polymorphism and the components of DAS28 (change (Δ) between baseline and follow-up of swollen and tender joint counts (SJC and TJC), CRP and patient global score).