Furthermore, TCGA data portal (Figure 8K) shows that human PDACs exhibit amplifications and mutations in ADAM10, MYC, VIM (vimentin), CD44, CCND1 (CyclinD1) and CTNNB1 (β-catenin), implying the importance of interfering with the signaling associated with these in prevention of pancreatic cancer. Here, ADAM10 is linked to familial pancreatic carcinoma.