This suggests that one of the mechanisms by which aberrant calcium signaling enhances cancer cell growth and metastasis could be through enhanced Rab-mediated recruitment of ADAM10 and its substrates to the plasma membrane, where ADAM10 actively cleaves its substrates, such as cadherins, CD44, Notch and APP, to promote growth, EMT, migration, invasion and metastasis of cancer cells. The gene discussed is CD44; the disease is cancer.