Altogether, these findings along the miRNA/mRNAs (miR-145-5p/EGFR-cMYC-MUC1-OCT4-TPD52) network here documented raise the possibility of, combining epigenetic drugs with conventional chemotherapy and oncogene-targeted therapeutics might hold great promises for rational-based therapeutic management of metastatic tumors. This evidence concerns the gene POU5F1 and metastatic neoplasm.