Restoration of miR-145-5p expression using either vorinostat or 5-azacytidine, which released methylation of the miR-145 locus, led to inhibition of migration of lung cancer cells and to down-regulation of OCT-4, MYC, EGFR, MUC-1 and TPD52 expression. The gene discussed is EGFR; the disease is lung cancer.