SHB and melanoma: Up to 56 genes associated with MITF binding sites were co-regulated by BPTF, including BIRC7 SHB, and BCL2A1 critical regulators of proliferation, apoptosis and survival, NPM1 an important cell cycle regulator involved in chromosome congression, spindle and kinetochore-microtubule formation required for normal centrosome function [39,40] and PPARGC1A (PGC1α) implicated in resistance to oxidative stress and mitochondrial function in melanoma [41,42] (S4C Fig).