Direct interactions of human Tra2-β with two such novel splicing factors, hnRNP-G and SRp30c modulate the inclusion of exon7 of the survival motor neuron gene (SMN2) in the final transcript, preventing the lethal condition of proximal spinal muscular atrophy (SMA) [32, 33]. This evidence concerns the gene TRA2B and proximal spinal muscular atrophy.