Additionally, PCSCs carrying shControl, shGLUD1, and shGOT1#2 were subjected to 2 weeks of culture with fractional IR treatment, and suppression of GOT1—but not GLUD1—significantly increased radiosensitivity in PCSCs from both pancreatic cancer cell lines (Fig. 5C). This evidence concerns the gene GOT1 and familial pancreatic carcinoma.