Among the most differentially expressed miRNAs between SH-SY5Y and LAN-5 cell lines, we chose miR-101, miR-34a, miR-424, miR-21, miR-504 and miR-92a which clearly represent the phenotypic differences between the two cell lines as concerns tumorigenicity and NB tumor progression, regulation of cell cycle, differentiation and targeting of MYCN. The gene discussed is MYCN; the disease is neuroblastoma.