CCND1 and mantle cell lymphoma: Moreover, based on our previous evidence of an involvement of the translocation t(11;14) in PF-00477736 sensitivity [24], we evaluated the expression of cyclin D1, that the translocation in MCL renders constitutively active, and a decrease in its expression levels (both mRNA and protein) could be observed in JEKO-1 R cell line (Figure 3A-3B and Supplementary Figure 3).