The combination of ABT-263 (navitoclax, a chemical inhibitor of the BCL2 family) and a MEK inhibitor shows synergistic effects in KRAS mutant CRC xenografts [23], and this combination is currently being tested in a Phase I/II clinical trial (ClinicalTrials.gov ID: NCT02079740). Here, MAP2K7 is linked to colorectal carcinoma.