IFNG and chronic rhinosinusitis with nasal polyps: In the ROC curve analyses, the cutoff of the IL–5, periostin, IFN-γ, and E/M ratio for patients with non-eosinophilic CRSwNP was <2.379 (sensitivity of 77.4%, specificity of 60.7%), <3.889 (sensitivity of 75.8%, specificity of 74.2%), >0.316 (sensitivity of 78.1%, specificity of 74.2%), and <2.167 (sensitivity of 75.0%, specificity of 60%) in the study population, respectively (Fig 5).