The areas under the ROC curve for patients with non-eosinophilic CRSwNP were 0.7656 of IL–5, 0.7542 of periostin, 0.8251 of IFN-γ, and 0.7889 of E/M ratio, respectively in the study population. This evidence concerns the gene POSTN and chronic rhinosinusitis with nasal polyps.