APOE and Alzheimer disease: Importantly, the intra-network and inter-network patterns of the resting-state connections in subjects with AD and autosomal dominant AD and individuals at high risk (family history, APOE-4 allele and amyloid burden) for AD have been well studied, and the results have demonstrated that the large-scale brain networks are vulnerable in AD patients and in individuals at high risk of converting to AD25, 36, 37, 38, 39, 40, 41, 42.