Recently, there exists evidence that microRNAs (miRs), such as miR20a, miR–93, miR-106b, miR–372 and miR-520d could have been described to control the constitutive and/or IFN-γ-induced expression of NKG2D ligands in tumor and virus-infected cells [19–21], and the knock down of the miR biogenesis enzyme DICER upregulated MICA/B expression [22]. This evidence concerns the gene MICA and neoplasm.