Surprisingly, Gefitinib downregulated the basal expressions of MICB and ULBP–2/5/6 in PC–9 cells (Fig 4B) and MICA in A549 (S4B Fig), although Gefitinib did not show any effect in the other carcinoma lines tested (S5 Fig). The gene discussed is ULBP2; the disease is carcinoma.