PLK4 and neoplasm: Combining these findings with the facts that KLF14 KO causes spontaneous tumorigenesis in multiple organs, tumours from KLF14-KO mice exhibit amplified centrosomes with Plk4 upregulation and KLF14 deficiency promotes AOM/DSS-induced colon tumour formation in vivo, we suggest that KLF14 reduction can promote Plk4-directed centrosome amplification and consequently increase risks of tumour formation.