Likewise, HOXA1, found to be mutated in lung adenocarcinoma, is associated with a hypermethylation phenotype (Tsou et al., 2007; Selamat et al., 2011); hence, it might be targetable by DNA methyltransferase inhibitors, such as decitabine and azacitidine, suggesting a molecularly stratified treatment strategy for this patient population. This evidence concerns the gene HOXA1 and lung adenocarcinoma.