PTEN and acute myeloid leukemia: In addition to pan-cancer recurrent genes, such as PTEN, which are mutated at high frequency in multiple cancers, this analysis also revealed a number of genes that are more uniquely mutated in specific cancer types; for instance, ABL1 in acute myeloid leukemia (AML) and HOXA1 in lung adenocarcinoma (Fig. 5B).