In addition to novel links, the network analysis also identified missing players between these four genes, including RAS oncogene, EGFR and BCR, all of which are well established as having a role in the pathogenesis and treatment of many cancer types, including breast, colorectal, pancreatic and lung cancer; these molecules are either serving as biomarkers for cancer prognosis and/or prediction of treatment efficacy (supplementary material Fig. S8). The gene discussed is EGFR; the disease is cancer.