We introduced the Rgs16::GFP reporter into KC and KIC mice because PDA initiates in pancreatic duct-like cells, either following ADM or neoplastic growth of progenitor cells, anywhere from the head to the tail of the pancreas but not in the hepatopancreatic duct (supplementary material Fig. S1) (Aguirre et al., 2003). Here, CALCA is linked to Patent ductus arteriosus.