BRCA1 and neoplasm: Treatment of KPC mice from 8 weeks of age with the smoothened inhibitor IPI926 demonstrated that long-term inhibition of hedgehog signalling actually accelerates tumour development and decreases survival (Rhim et al., 2014), whereas treatment of KPC-Brca1 mice at the same time point with the DNA demethylating drug 5-aza-2′-deoxycytidine (decitabine) significantly inhibited tumour growth (Shakya et al., 2013).