In Pdx1-Flp;FSF-KrasG12D/+;FSF-R26CAG−CreERT2/+;Trp53lox/lox mice (KPF), the deletion of Trp53 2 months after the expression of oncogenic Kras in the pancreas induces rapid multifocal tumour development (Schönhuber et al., 2014). Here, TP53 is linked to neoplasm.