Whereas HA depletion by PEGPH20 resulted in improved vasculature and increased gemcitabine delivery, blocking CTGF decreased the expression of the pro-survival protein XIAP (X-linked inhibitor of apoptosis) and induced the killing of tumour cells (Jacobetz et al., 2013; Neesse et al., 2013). The gene discussed is XIAP; the disease is neoplasm.