KRAS and cancer: Indeed, results obtained from this model have identified the activation of Yap1 (Yes-associated protein 1) – a transcriptional co-activator in the Hippo pathway that controls cell proliferation, apoptosis and thus organ size, and is frequently overexpressed and activated in different cancers (Zhang et al., 2014) – as a potential bypass mechanism to overcome the dependence of PDAC on oncogenic Kras (Kapoor et al., 2014).