Urinary connective tissue growth factor (CTGF) and TGF-β are increased in micro- and macroalbuminuric DN [85, 86] and may reflect the occurrence of underlying fibrosis that may be used as a marker for disease progression; 15-kDa intracellular carrier protein liver-type fatty acid binding protein (L-FABP) found in the liver and proximal tubular cells is a marker of structural and functional renal tubular damage. Here, CCN2 is linked to liver dysplastic nodule.