Notably, the amount of S100A8 in vivax malaria patients was three times higher than that in healthy volunteers (Fig. 1), and the mean value of S100A8 produced by vivax malaria patients (141.2 ng/ml) was less than that of falciparum malaria patients (3420 and 13,580 ng/ml for parasitaemia <0.2 and ≥0.2 %, respectively) [20]. This evidence concerns the gene S100A8 and Plasmodium falciparum malaria.