A randomized, double blind, placebo-controlled trial of G-CSF has been performed in afebrile outpatients with severe chemotherapy-induced neutropenia [24]: G-CSF shortened the duration of neutropenia, but did not decrease the hospitalization rate for FN, length of hospital stay, the number of days of antibiotic therapy, and the likelihood of having a positive culture. This evidence concerns the gene CSF3 and Decreased total neutrophil count.