TP53 and large cell carcinoma: Calu6 is being sequenced in the Catalogue of Somatic Mutations in Cancer (COSMIC) Cell Lines Project at the Sanger Center, Cambridge, UK and has a homozygous missense point mutation (R196*) in TP53. Of the other cell lines, H460 is a large cell carcinoma with wild-type TP53, 201 T is a lung adenocarcinoma with wild-type TP53, and 54 T and 239 T are lung squamous cell carcinomas with wild-type TP53.